Free Ebook Download - Human Drug Metabolism - An Introduction, 2 edition

Free Ebook Download - Human Drug Metabolism - An Introduction, 2 edition
Detail : 
Paperback : 363 Pages | Language : English
File Size : 1.66 Mb | File Format : PDF

Description:

Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare.
After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.

About The Author:

Born 1960 in Crosby, near Liverpool (UK), some of Michael Coleman's earliest external influences included Liverpool's music scene and American cars of the late 1960's. Although he moved to the US in the late 1980's and owned a yellow V8 Dodge, which he spent some time rodding up and still misses, as he gave it to his friend who SOLD IT!! to someone else...When he returned to the UK he started driving Volvo's as he was sick of his earlier British cars disintegrating under him. Whilst he admires the engineering and reliability of Volvos and now knows a great deal about them, he sorely misses his beloved Dodge. He would really like a '68 Charger which he considers to be the zenith of the motoring world and is unsurpassed for sheer soul-churning beauty and sound. He sometimes watches the famous 9 min sequence in 'Bullitt' with tears in his eyes..you know the one. He sat in a '68 in 1988, but the guy mentioned he had sold it already to a 'dude with a GTO, but if you got more dough man, we can deal'. Michael's sense of fair play prevented him from accepting this offer. Although he can afford it now, he is basically too tight-fisted to buy a sixties Caddy, which would the the next best thing to a Charger. It's highly likely that his wife would give him a very hard time if he bought such a car also, but hey, whaddyagonna do? His music career in slide and blues guitar has so far resolutely failed to emerge from Marianas Trench levels of obscurity. Although technically capable and he has a deep love of the blues, he lacks the inspiration to write memorable songs. Michael has been particularly struck at the supernatural power of some songs to retrieve dying gigs ('No Particular Place to Go' and Pinball Wizard') so as he is unable to approach such towering genius, he will have to stick with his day job, which is science. This is just as well, as although he gave up drinking and smoking some time ago, he would probably mis-behave conspicuously on tour, disgrace himself comprehensively and probably end up like Nicky Sixx...or worse. Michael retains a profound admiration for the works of the first incarnation of Van Halen, as well as The Cult and has been a devoted student of Hendrix for more than 20 years. He is writing this biography to avoid the vast pile of marking obscuring his desk but is now resigned to having to finish the job-after all, somebody had to mark his virtually illegible stuff years ago. He also realises, that science, rather like our parents, gives us life and although we love it really and could not live without it, we don't always admit it.

Contents: 

1     Introduction.
1.1     Therapeutic window.
1.2     Consequences of drug concentration changes.
1.3     Clearance.
1.4     Hepatic extraction and intrinsic clearance.
1.5     First pass and plasma drug levels.
1.6     Drug and xenobiotic metabolism.

2     Drug Biotransformational Systems – Origins and Aims.
2.1     Biotransforming enzymes.
2.2     Threat of lipophilic hydrocarbons.
2.3     Cell communication.
2.4     Potential food toxins.
2.5     Sites of biotransforming enzymes.
2.6     Biotransformation and xenobiotic cell entry.

3     How Oxidative Systems Metabolize Substrates.
3.1     Introduction.
3.2     Capture of lipophilic molecules.
3.3     Cytochrome P450s classifi cation and basic structure.
3.4     CYPs – main and associated structures.
3.5     Human CYP families and their regulation.
3.6     Main human CYP families.
3.7     Cytochrome P450 catalytic cycle.
3.8     Flavin monooxygenases (FMOs).
3.9     How CYP isoforms operate in vivo.
3.10    Aromatic ring hydroxylation.
3.11    Alkyl oxidations.
3.12    ‘Rearrangement’ reactions.
3.13    Other oxidation processes.
3.14    Control of CYP metabolic function.

4     Induction of Cytochrome P450 Systems.
4.1     Introduction.
4.2     Causes of accelerated clearance.
4.3     Enzyme induction.
4.4     Mechanisms of enzyme induction.
4.5     Induction – general clinical aspects.

5     Cytochrome P450 Inhibition.
5.1     Introduction.
5.2     Inhibition of metabolism – general aspects.
5.3     Mechanisms of inhibition.
5.4     Cell transport systems and inhibition.
5.5     Major clinical consequences of inhibition of drug clearance.
5.6     Use of inhibitors for positive clinical intervention.
5.7     Summary.

6     Conjugation and Transport Processes.
6.1     Introduction.
6.2     Glucuronidation.
6.3     Sulphonation.
6.4     The GSH system.
6.5     Glutathione S-transferases.
6.6     Epoxide hydrolases.
6.7     Acetylation.
6.8     Methylation.
6.9     Esterases/amidases.
6.10    Amino acid conjugation (glycine or glutamate).
6.11    Phase III transport processes.
6.12    Biotransformation-integration of processes.

7     Factors Affecting Drug Metabolism.
7.1     Introduction.
7.2     Genetic polymorphisms.
7.3     Effects of age on drug metabolism.
7.4     Effects of diet on drug metabolism.
7.5     Gender effects.
7.6     Smoking.
7.7     Effects of ethanol on drug metabolism.
7.8     Artifi cial livers.
7.9     Effects of disease on drug metabolism.
7.10    Summary.

8     Role of Metabolism in Drug Toxicity.
8.1     Adverse drug reactions: defi nitions.
8.2     Reversible drug adverse effects: Type A.
8.3     Irreversible drug toxicity: Type B.
8.4     Type B1 necrotic reactions.
8.5     Type B2 reactions: immunotoxicity.
8.6     Type B3 reactions: role of metabolism in cancer.
8.7     Summary of biotransformational toxicity.

Appendix A          Methods in Drug Metabolism.
A.1     Introduction.
A.2     Analytical techniques.
A.3     Human liver microsomes.
A.4     Human hepatocytes.
A.5     Human cell lines.
A.6     Heterologous recombinant systems.
A.7     Animal model developments in drug metabolism.
A.8     Toxicological metabolism-based assays.
A.9    In silico studies.
A.10    Summary.

Appendix B          Metabolism of Major Illicit Drugs.
B.1     Introduction.
B.2     Opiates.
B.3     Cocaine.
B.4     Hallucinogens.
B.5     Amphetamines.
B.6     Cannabis.
B.7     Dissociative anaesthetics.

Appendix C          Examination Techniques.
C.1     Introduction.
C.2     A fi rst-class answer.
C.3     Preparation.
C.4     The day of reckoning.

Appendix D         Summary of Major CYP Isoforms and their
Substrates, Inhibitors and Inducers.

Direct Link Download: 

Mediafire: Free Ebook Download - Human Drug Metabolism - An Introduction, 2 edition

Rapidgator: Free Ebook Download - Human Drug Metabolism - An Introduction, 2 edition