Vaccines against Allergies

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Book Detail 

Hardcover: 193 pages

Publisher: Springer; 2011 edition (August 31, 2011)

Language: English

ISBN-10: 3642200532

ISBN-13: 978-3642200533

File Size : 1.46 Mb | File Format : PDF

Book Description 

We are celebrating this year the hundred years´ anniversary of allergen-specific immunotherapy. In 1911 Leonard Noon published his seminal work “Prophylactic inoculation against hay fever” describing his attempts to achieve active immunity against “grass pollen toxin” by administering increasing doses of grass pollen extract before the grass pollen season to allergic patients. Although it was unknown at that time that allergy represents an immunological hypersensitivity disease, the treatment was effective and many observations made by Noon remained valid until today. Today allergen-specific immunotherapy is well established as the only allergen-specific and disease-modifying treatment for IgE-mediated allergies and has long-lasting effects. In fact, more than 25% of the population suffer from IgE-mediated allergies which therefore represent a major health burden of our society, particularly because untreated allergy often progresses to severe disabling forms of disease, such as asthma and sometimes kills sensitized people through anaphylaxis.

Table of Contents 

Immunological Approaches for Tolerance Induction in Allergy
Melanie L. Conrad, Harald Renz and Kurt Blaser

Clinical Experience with Recombinant Molecules for Allergy Vaccination 
Oliver Cromwell, Verena Niederberger, Friedrich Horak and Helmut Fiebig

Allergen-Specific Immunotherapy with Recombinant Allergens 
G. Pauli and Hans-Jørgen Malling

Vaccine Approaches for Food Allergy 
Philip Rancitelli, Alison Hofmann and A. Wesley Burks

Intralymphatic Immunotherapy: From the Rationale to Human Applications
Gabriela Senti, Pål Johansen and Thomas M. Kündig

Induction of Allergen-Specific Tolerance via Mucosal Routes 
Laurent Mascarell, Aline Zimmer, Laurence  Van Overtvelt, Sophie Tourdot and Philippe Moingeon

T Cell Epitope-Based Allergy Vaccines
Mark Larché

Allergen-Specific Immunotherapy: Towards Combination Vaccines for Allergic and Infectious Diseases
Johanna Edlmayr, Katarzyna Niespodziana, Margarete Focke-Tejkl, Birgit Linhart and Rudolf Valenta

Passive Immunization with Allergen-Specific Antibodies 
Sabine  Flicker,  Elisabeth  Gadermaier, Christoph Madritsch and Rudolf Valenta

Cell-Based Therapy in Allergy 
Ulrike Baranyi, Martina Gattringer, Rudolf Valenta and Thomas Wekerle

Index

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